The Big Ten won the Challenge last year, 6-5.
Boston College (4-1): The Eagles host Indiana (6-0) Wednesday in their game against Big Ten foe. Indiana is 23rd in the nation in shooting percentage shooting 49 percent. Sophomore Christian Watford led the Hoosiers with 18 points a game and seven rebounds.
Clemson (5-1): The Tigers host Michigan (3-2) Tuesday to represent the ACC in the challenge. Senior guard Demontez Stitt will work on stopping freshman guard Tim Hardaway Jr. and sophomore guard Darius Morris who lead the Wolverines in scoring.
1Duke (6-0): The Blue Devils will host No. 2 Michigan State (5-1) Wednesday in a rematch of last years championship matchup, and the meeting could be a rematch again later in March.
Freshman guard Kyrie Irving gets his chance to prove himself against the Spartans returning leader Kalin Lucas. Nolan Smith and Kyle Singler lead a Blue Devils team that is fourth in the nation in scoring (91 points).
After the Big Ten opponent, Duke hosts No. 23 Butler (3-2) Saturday in another rematch from last years tournament. Dukes offense is clicking, so these teams will have to find a way to disrupt the rhythm to even have a chance.
Chris Singleton is on a roll scoring a triple double and three double doubles his previous four games.
Senior David Lighty leads an Ohio State offense that shoots 52 percent (8th in the nation). Freshman Aaron Craft averages five assists for the offense that is eight in the nation in assists with 19 per game.
Brian Oliver and Iman Shumpert will have to get the Yellow Jackets offense going against Northwestern offense with two players averaging 20 points. John Shurna averages 22 for Northwester and shoots 65 percent from beyond the arc, and Drew Crawford averages 20 points.
25 North Carolina (3-2): The Tar Heels have been matched against No. 19 Illinois (6-1) on the road Tuesday.
The Terps gave Illinois all they could handle in New York earlier this year, and Heels freshman Harrison Barnes has to show up. Illinois has players that can score and rebound, and senior Tyler Zeller will be challenged by the defense.
After facing Illinois, the Heels host No. 9 Kentucky Saturday. Terrence Jones leads the Wildcats high powered offense. The Tar Heels should score a lot of points if they want to hang with these two teams.
N.C. State (4-1): Many Wolfpack players get to play in their first ACC/Big Ten Challenge Wednesday on the road against Wisconsin (4-1).
Saturday, they travel to No. 10 Syracuse (6-0) to finish their two-game road trip. Syracuse has been in many close games this year, and N.C. State will be battling the Wisconsin crowd.
The Gophers have already beaten the Tar Heels when they were ranked No. 8, and the Cavs will have to contain their well rounded offense. Senior guard Blake Hoffarber operates the offense and leads them in scoring with 15 points per game, and adds five assists and nearly two steals per game.
Senior guard ETwaun Moore leads Purdue with 20 points per game and seven rebounds. Senior guard Malcolm Delaney leads the Hokies.
Wake Forest (3-3): The Demon Deacons face Iowa (3-3) in the Challenge on Tuesday. Iowa has potential to give up a lot of points, and freshman Travis McKie and sophomore Ari Stewart are averaging a combine 29 points.
Saturday, they host Holy Cross (0-5) who struggle to score points and are led by junior guard Devin Brown.