Defensive line coach Mike DuBose and linebackers coach Galen Scott will replace Hopson as co-defensive coordinators.
In the Tigers' two games this season, the defense gave up over 600 yards and has allowed an average of 53 points a game.
According to Porter, DuBose will continue to oversee the defensive line. Scott will also still be responsible for the linebacker unit, while Shannon Morrison will coach the secondary.
Hopson came to the U of M in 2009 after spending two seasons at Michigan as the linebackers coach. From 2005-07, Hopson guided the Southern Miss defense. In 2007, Hopson was named the All-American Football Foundation Top Assistant Coach.