"They like to blitz a lot, so we just gotta figure out where the blitzes are going to come from and react based on that," he said.
Cook, who is coming off a 22 of 31 passing performance against Indiana, said the Boilermakers will dial up blitzes much more than the Hoosiers did.
"They mess around with their defensive linemen," he said. "Indiana had a lot of four-down stuff. Purdue, they will have their three down linemen and they will walk up another stand-up end or another linebacker as a pass rusher.
"They want to try and confuse you where the pressure is going to come from. I just feel like they bring a lot more pressure than Indiana and that's what we have to be ready for."
Cook was sacked once against the Hoosiers and only has been sacked twice in his past three starts.
He said the blitz packages Purdue will bring provide a challenge for him as a quarterback.
"You just gotta change protection if they are going to blitz one way and kind of redirect the protection one way so you can slide and pick it up," he said.
Cook has thrown for 923 yards and nine touchdowns on 90 of 156 passing this season.