But has been an issue throughout his career, Jones went down with an MCL injury against Notre Dame and has been out ever since.
The Spartans originally hoped he would miss a few weeks, but coach Mark Dantonio said Jones will require surgery.
"Jairus is out for the season," he said. "They've re-evaluated that."
Dantonio said despite another injury, Jones has remained strong in his leadership.
"He's an outstanding young man and concentrating on graduating now at midseason and it's too bad, because he's an outstanding player," he said. "He's struggled a lot with injuries.
"He won't get this year back because he's already been redshirted in that capacity."
Dantonio also said the bye week is a good time for senior defensive tackle Tyler Hoover to get back healthy after missing the past two games.
"Well, that's a tough one to gauge, so I hope he is," he said. "I think he could have played some on Saturday but he wasn't 100% so that was the main focus.
"We need to get him 100%, he needs to start making plays for us. He's a good football player but he's been a little quiet lately."