Coach Tom Izzo said the chances of Payne playing are "slim to none."
"He is champing at the bit to play," Izzo said. "It ain't about a game. It's about his career and our big picture of things."
Payne has been cleared to work out and has done some running workouts.
"He's run on the treadmill twice for a matter of 20 minutes and at about 60 percent of his body weight," Izzo said. "They can put him in a harness and that's what he's done. (Unfortunately), they don't let us have those on a floor."
The Spartans have won all four games without Payne. They also will be without junior forward Branden Dawson, who broke his hand Thursday when he punched a table out of frustration during a film session.