Anderson led the Spartans with 22 points and 10 rebounds, while Hill chipped in with 21 points. Hill went 5-of-8 from three-point land to end the game with 304 career treys; which is second all-time in Spartan history behind Shawn Respert's 331.
Harvey, a walk-on during his entire four-year career at Michigan State, earned his first start Saturday night. He recorded his first field goal as a Spartan in the game's opening minutes, scoring on a put back that resulted in a three-point play. He finished the game with 3 points and 2 rebounds in eight minutes of action.
The Spartans (22-5, 13-3 Big Ten), who will be the number two seed in the upcoming conference tournament, won their eighth game in nine outings and defeated the Nittany Lions for the sixth consecutive time.
Anderson has topped 20 points in three of his last four games after going 116 consecutive games without scoring 20.
Penn State (7-22, 1-15) tried to spoil Senior Night by using a 16-4 run, highlighted by eight points by Ben Luber, to take a 20-12 lead in the first eight minutes.
But Michigan State responded with four consecutive 3-pointers, including a pair by Maurice Ager in a 14-2 run, which helped give the Spartans a 39-35 lead at the break.
After the early run, Penn State was completely throttled by the Spartan defense. Penn State's leading scorers, Geary Claxton and Aaron Johnson, who entered the game averaging 12.5 and 12.3 points-per-game, respectively, were held to a combined 13 points on a combined 4-for-13 shooting.
Anderson and Hill combined for 12 points as Michigan State opened the second half with a 14-2 run to extend the margin to 53-37 just five minutes in. Michigan State continued to roll from there, outscoring Penn State, 39-9 to begin the second half to finish the rout.
The Spartans shot 55 percent (21-of-38) from the floor in the second half, forced 23 turnovers for the game and outrebounded the Nittany Lions, 37-28. Coming into the game, Penn State averaged a league-leading 12.71 offensive rebounds per game. Michigan State held the visitors to only seven offensive boards, while the Spartans grabbed 16.
The Spartans recorded their highest assists total of the season, with 28 on 36 baskets, and turned the aforementioned 23 Penn State turnovers into 32 points of their own. Michigan State was also productive from behind the arc, going 13-of-26 (.500).
Ben Luber and Mike Walker scored 12 points each for Penn State, which has lost 11 straight games and has dropped all 14 contests against the Spartans at East Lansing.
Due to their status as a #2 seed, Michigan State will have a first-round bye in next week's Big Ten tournament. The Spartans have won eight of their last nine games to enter the postseason, with their only loss coming in overtime at Indiana, 78-74, one week ago.
Penn State, the Big Ten's last-place team, lost its 11th straight game and will play in a first-round game Thursday.