This year, the Spartans go on the road as many players will be coming back to their home state of Ohio, marking a special feeling of playing in front of family and friends.
"Me, Ashton (Watson) and Javon Ringer are all from Dayton too. Me and Javon went to the same high school so we talk about it all the time; it's an exciting game for us," said Spartan defensive tackle Brandon McKinney.
McKinney was recruited by Ohio State and was committed there until his academics fell off and he recommitted to Michigan State.
"I'm going back home; I was going to Ohio State but things just didn't work out" said McKinney," it's just another chance for me to get back at them."
Besides McKinney, Watson, and Ringer, the Spartans have a load of Ohio players on the squad: Punter Brandon Fields (Toledo), Kicker John Goss (Grove City), Linebacker David Herron Jr. (Warren), and Safety Eric Smith (Groveport).
"Us Ohio guys, we talk about it every now and then and say we can't lose in Ohio, we got to come ready to play and I think it will give us some motivation," said Eric Smith, whose hometown of Groveport is located just fifteen minutes from the Ohio State campus.
Overall, there are 16 players on MSU that hail from Ohio, and with about half of them being starters, they should be more than ready to play an Ohio State team that is vulnerable and trying to get back on track after a loss to Penn State last week.
"It's a great atmosphere," said head coach John L. Smith on playing at Ohio Stadium. "I try to talk to the guys a lot about how special they are to get to play the game, number one, and then to get to play in the venues we get to play in."
Ohio Stadium will have a capacity crowd of more than 102,000 fans attending the game on Saturday.
"Some (venues) are bigger than others, without a doubt, but it's about as big as it is," said John L. Smith.
Considering the importance of this game to the Spartans' hopes for a Big Ten Title, they will need to put any personal issues aside and fully focus on Ohio State.