On a special day where ESPN's College Gameday visited campus, the Spartans (21-8, 8-6) closed out their home schedule at 18-1 by outscoring the Hoosiers (18-9, 8-6) 46-28 in the second half, including 15 of Neitzel's 17 coming in the second half.
"This team is tough, and they played hard," said Michigan State coach Tom Izzo. "But it was a gutsy effort by us as you probably could see. Drew Neitzel is sicker than a dog and he just battled through it."
"I didn't know how long he (Neitzel) was going to be able to go, so I did him a favor--I rested him a minute. Otherwise, I would have played him all forty minutes," Izzo added.
Hoosiers led 30-20 at halftime and increased their lead early in the second half to 13 points before an 8-0 MSU run sparked by a Neitzel three-pointer.
A three-point play by Walton at 10:05 of the second half gave the Spartans their first lead of the game at 40-39.
It was Walton again who came up big on the other end after a Hoosier timeout, as he stripped the ball out of Roderick Wilmont's grasp and fed Raymar Morgan for an open drive to the basket. Morgan made both free-throws after getting fouled on the play, making the lead 42-39.
MSU would never give the lead up again, with a jumper by Neitzel with 5:25 left in the game increasing the Spartan lead to 56-46.
The Spartan defense came up big in the game, holding Indiana's leading scorer, D.J. White to only 9 points while their second leading scorer, Wilmont went scoreless in the game.
MSU overcame 23 turnovers while out rebounding the Hoosiers 31-21 in the game.
With the win, the Spartan are now tied with Indiana for third place in the Big Ten standings at 8-6.
Following the game, the Spartan players came out and ran circled the court greeting the fans still left in the stands, thanking them for another great year of basketball at Breslin Center.
"That was the coaches and players idea to run around the court. We just wanted to thank the fans for doing a great job for us at home and sticking with us," said Walton.
Michigan State now travels to Ann Arbor to face Michigan on Tuesday night for a chance to climb the Big Ten standing and break the tie with several other teams.