Arizona (10-0) got off to a rare fast start and kept the accelerator down, quickly turning a highly-anticipated nonconference game into a rout.
The Wildcats dominated inside, outscoring Michigan 42-16 in the paint and grabbing 14 more rebounds for their 28th consecutive home win.
Kaleb Tarczewski had 15 points and seven rebounds for Arizona, which shot 58 percent to win its 37th straight regular-season nonconference game.
Michigan (6-4) capped off a disappointing week with a dismal performance.
The Wolverines fell into a quick double-digit hole and struggled against Arizona's defense all day, shooting 35 percent for their first three-game losing streak since 2010-11.
Zak Irvin led Michigan with 14 points.
Michigan had taken a pretty big stumble over the past week, leaving the Wildcats a little wary of the Wolverines.
Michigan was the victim last weekend in one of college basketball's biggest upsets in recent years, losing 72-20 to New Jersey Institute of Technology, a 24-point underdog. The hangover still lingering, the Wolverines lost to Eastern Michigan after scoring 42 points against the neighboring school.
What worried Arizona was a bounce-back game by Michigan.
The Wolverines played in the Elite Eight last season - as did Arizona - and beat Syracuse earlier this year, so they're still a talented team. They also figured to be a little angry after two unexpected home losses.
The Wildcats made their mood a little worse.
Plagued by slow starts this season, Arizona made eight of its first nine shots to go up 20-9. The Wildcats kept dropping shots and filling up the highlight reel, going up 33-17 on a jump-out-of-the-gym, one-handed alley-oop by Johnson on a feed from York in transition.
Arizona made 15 of shots 24 in the first half, building a 36-25 lead.
Michigan kept up for the first few minutes, but faded quickly against Arizona's pressure.
The Wolverines went more than 7 minutes without a field goal and shot 7 of 22 in the opening half.
Little changed to start the second half.
Michigan missed its first six shots while Arizona had the fans leaping out of their seats every few trips down the floor.
The Wildcats opened with an 11-0 run highlighted by Ashley's two-handed alley-oop on an inbound play and York's 3-pointer from the corner.
Michigan: Irvin made 6 of 13 shots after going 5 for 23 the previous two games. ... The Wolverines shot 7 of 26 from 3-point range.
Arizona: The Wildcats had 19 assists and 10 turnovers. ... Johnson had 13 points on 6-of-8 shooting in the first half.
Michigan hosts Southern Methodist next Saturday.
Arizona hosts Oakland on Tuesday.