Austin Parkinson stole a loose ball and went in for a layup to give the Boilermakers a 50-41 lead. Gophers coach Dan Monson was issued a technical foul for arguing that Parkinson held Adam Boone on the play, and Lowe's free throw gave Purdue a 51-41 lead.
Boone hit back-to-back three-pointers to bring the Gophers within 58-56 with 7:30 to play and Maurice Hargrow tied the game with two free throws just over a minute later.
Hargrow's free throws capped an 11-0 run that erased a 15-point halftime deficit for Minnesota.
Forward David Teague made 5 of 10 from the field, 4 of 7 from three-point range and 4 of 4 from the line, as he led Purdue with 18 points.
Purdue made 23 of 43 (53.5%, a season-best) shots and was 8 of 14 (57.1%) from three-point range.
The Gophers shot just 39.3% (22 of 56) from the field.
The Boilermakers took advantage of Humphries' eye injury, shooting 63 percent in the first half to take a 43-28 lead. Teague and Lowe combined for 30 of the team's 43 first-half points. Purdue went on a 12-0 run to go up 16-4 with 10:50 to go in the first half. Purdue made 7 of 11 from three-point range in the first half.
Teague had 16 points, including four 3-pointers, and Lowe added 14 in the first half to key the fast start.
Freshman Kris Humphries, who is the Big Ten's leading scorer and rebounder, played most of the game with his left eye nearly swollen shut after he was elbowed by Buscher midway through the first half. Humphries went to the bench throughout the final 30 minutes to ice his eye. Humphries led the Gophers with 19 points. However, he was just 5 of 15 from the field. He did make all eight free throws.
Stanley Gaines, who moved into the starting lineup two weeks ago, continues to shine as he scored 14 points. He made 5 of 8 from the field and 4 of 5 from the line.
Adam Boone, who has struggled with his shooting most of the season, made 3 of 5 from three-point range and 4 of 7 from the floor to finish with 12 points.
The Gophers return home to face Indiana on Saturday.