The home standing and top seeded Yellow Jackets will take on #4 seed Austin Peay, the Ohio Valley Conference champions.
The Golden Eagles along with other Bulldog non-conference opponents Alcorn State, Belmont and Sacred Heart earned their way in the 64 team field.
Mississippi State was one of seven SEC baseball teams to advance to the national tournament.
Florida, Georgia and South Carolina will all open their runs for the title at home by virtue of being named one of the tournaments top eight national seeds.
Mississippi State has met all three regional opponents on the field of play before.
The Bulldogs have an All-Time record of 3-2 against Austin Peay with the last contest coming in 2008.
Mississippi State holds a 7-3 advantage over Georgia Tech, but the two programs have not played against one another since 1997.
The Bulldogs are 75-36 All-Time against the Golden Eagles of Southern Miss with the most recent meeting taking place this year.