Mixon caught seven passes for 159 yards and accounted for three touchdowns, but none was bigger than the last one.
With the game on the line, Mixon reeled in a 4th down pass and sprinted 68 yards to give Auburn the win.
Shades Valley (1-0) will play Bessemer City next week.
Kendell Jones and Clay-Chalkville had an impressive 44-23 win over Niceville before a nationally televised audience.
Jones was active and disruptive throughout the contest.
The final score is not truly indicative how lopsided the match-up truly was.
Minor was idle this week.
Justin Johnson and Hoover also played on the big stage as the Bucs fell to Miami-Central on a late field goal 24-21.
Johnson was targeted a few times and made a pair of acrobatic grabs.
Hoover will look to get back on track next week as they challenge another out of state opponent in Colquitt County, Georgia.
Nick Gibson ran for 116 yards and a score in a 27-21 loss to Hartselle.
Pinson Valley (0-1) will take on Oneonta next week.
Deddrick Thomas threw for two scores and ran for two more as Memphis-Central got by Hernando 33-23.
Thomas got his Memphis metro player of the year candidacy off on the right foot and will look to continue his strong play this week when Central (1-0) takes on Mitchell.
Nick Tiano played just over a quarter and a half as Baylor trounced Howard Tech 51-7.
Before giving way to his back up, Tiano was 5 for 8 for 155 yards and four touchdowns.
Baylor (1-0) will take on Webb this week.
Harrison Moon and Signal Mountain found a win over East Hamilton 28-19.
Moon and his squad will be back in action this week against Tyner Academy.
Malik Dear scored three touchdowns as Murrah routed Hazlehurst 50-6.
Dear spent most of the second half watching the backups as the Mustangs began thinking about the big match up with Provine in week two.
Both programs enter this week's tilt with a win under their belts.
Dontea Jones and Louisville got their title defense off to a strong start with a 41-18 shelling of Jim Hill.
Jones had seven catches for 98 yards and a touchdown.
Louisville will travel to Wilkinson County (0-1) next week.
Keith Joseph and the Pascagoula defense shut out Moss Point 28-0.
The Panther senior class will graduate having never lost to the arch-rival Tigers.
PHS will be back in action this week as Ocean Springs comes to town.
Jarvis Wilson and Tupelo earned an impressive road win over Lafayette 20-0.
The Golden Wave will play on their new blue turf for the first time ever next week when Center Hill pays a visit.
Chris Stamps had two pass break-ups and a handful of tackles before the first team Warren Central defense gave way to the back-ups at the beginning of the fourth quarter in a 38-6 win over Terry.
The Vikings (1-0) will host Callaway (0-1) next week.
Callaway and Tommy Champion were unable to get on the scoreboard last week as Forest Hill won a battle of attrition 12-0.
Jamal Peters and Bassfield are looking to three-peat this year. Peters opened that quest with a 24 yard touchdown grab in the first quarter.
Despite what Peters labeled a sloppy game, the Yellowjackets got by Seminary 37-17.
Bassfield will host 2013 state champion FCAHS next week in an important early season contest.
Jonnas Spivey had an impressive opening night as Bay Springs won 45-6 over South Jones in a cakewalk.
Spivey completed 7 of 9 passes for 128 yards and a touchdown to go along with 52 rushing yards and a score on the ground.
Bay Springs will take on Stringer next week in the annual Battle for the Bell.
Tim Washington and Yazoo City put together a solid defensive showing in an 18-8 win over Velma Jackson that included a safety brought from a tremendous pass rush.
Yazoo City (1-0) will take on Humphreys County next week.
Mark McLaurin and Collins suffered a setback against Taylorsville 19-12.
Both teams are expected to be in the post season this year.
Collins will look to get to .500 with a win at Heidelberg (0-1) next week.
Farrod Green and Wesson took it on the chin as Lawrence County won 59-6.
Green had one catch for twelve yards in the first half.
The Cobras will look to right the ship next week against Sumrall. Alec Murphy watched from the sidelines as his Nixa High team could only manage 51 yards without him.
Nixa fell to Helias High 27-2.
Murphy will be back in action soon, which will boost Nixa's offensive punch.
Howell High is the opponent this week.
Cameron Myers and 6A defending champion Oak Grove will kickoff their season this week against Wayne County.
Texas High school football will kick off in earnest this week and Chason Virgil and West Mesquite will travel to Arlington for their first contest.
The MACJC opens its' season this week with Co-Lin hosting Itawamba on Thursday night.