Brinson opened the fifth with a single and later scored on a sacrifice fly by Jon Mungle to take a 5-0 lead.
MSU starter Paul Maholm (2-1) blanked the Lions with one-hit pitching through five innings before giving up a leadoff double to Jonathan Oller. Oller advanced on a sacrifice bunt and scored on Bill Lockin's grounder that was mishandled at second base. Maholm concluded his seven-inning showing with his sixth and seventh strikeouts. Chris Young worked the final two innings for MSU.
Steve Gendron and Michael Brown also turned in multi-hit plate performances with 2-for-4 showings. All 12 Bulldog hits were singles while two of LMU's three hits were doubles.
Huddy scattered nine hits and was charged with six of the seven bulldogs runs during his six-inning start for the Lions. Scott Sarver retired the three batters he faced in the the seventh and David Barba gave up a run on three hits in the eighth inning.
The teams resume their first-ever series Saturday at 2 p.m.
MISSISSIPPI STATE 7, LOYOLA MARYMOUNT 1
LMU (5-13) 000 001 000 - 1-4-1
MSU (8-1-1) 040 011 01x - 7-12-1
WP - Paul Maholm (2-1). LP - Kyle Huddy (1-1). T - 2:18. ATT - 1,356 (5,936 paid).