The Bulldogs jumped out to a 2-0 lead in the second when Brent Lewis opened the inning with a single, Steve Gendron followed with a double, and Michael Brown drove them home with a single to center field.
USM, blanked over the first four frames by MSU starter Ryan Carroll, scored its first run of the game on a fifth inning solo home run by Clint King. Carroll struck out three, walked two and gave up two hits in a career-longest 4.2 innings on the mound.
State used a pair of USM fielding miscues and a two-out single by Brent Lewis to take a 3-1 lead in the sixth. But USM answered quickly, scoring four times in the bottom of the sixth. Allen Winningham opened the inning with a double and both Jeff Cook and Griff Israel walked to load the bases. Clint Stoy singled in two runs, King followed with a run-scoring infield groundout, and a fourth run scored on a wild pitch. USM got a leadoff walk in the seventh, a sacrifice bunt and an RBI single by Cook to plate its final run in the seventh.
Young absorbed his first loss of the year for MSU. He was charged with four runs on two hits with a pair of walks.
The Bulldogs continue their five-game road run and open a three-game SEC Western Division weekend series Friday (6:30 p.m.) at Auburn (25-14, 7-8 SEC).
SOUTHERN MISSISSIPPI 6, MISSISSIPPI STATE 3
MSU ( 22-12-1) 020 001 000 - 3-4-0
USM (24-14) 000 014 10x - 6-5-3
WP - Daniel Stewart (3-2). LP - Chris Young (4-1). HR (USM) Clint King (3). T - 2:20. ATT - 3,835.