Mississippi State had not allowed an opponent to shoot over 50 percent this season, but Vanderbilt had no problem solving the Bulldogs' defense, shooting 63 percent in the first half.
Vanderbilt built a 22-point halftime lead and led by at least 17 the entire second half.
The Commodores bounced back from a disappointing overtime loss to South Carolina by playing one of their best first halves of the season, building a 46-24 lead. The 46 points was the most Vanderbilt has scored in any first half this season, and the Commodores had 16 assists on 17 baskets, with Alex Gordon leading the way with four assists.
Vanderbilt initially led 11-10 with 14:51 left in the first half, then outscored the Bulldogs 22-7 over the next six minutes to take a 33-17 lead. Foster had seven points during the run.
Vanderbilt's win snapped a five-game regular season Mississippi State winning streak in the series dating back to Feb. 21, 2001.
Mississippi State entered the game with an SEC-high 309 turnovers, and committed 21 against Vanderbilt.