Lewis threw three touchdown passes and led a last minute drive to set up the game winning field goal that led to the 22-21 shocking outcome.
With both 6A and 5A scalps on the wall, the Chiefs travel to Lawrence County in search of another and their third victory of the season.
For the second straight year Sandy Creek and East Coweta had to go to overtime to settle their affair.
This year Sandy Creek came out on the losing end of a 28-27 decision that saw a blocked extra point result in the margin of victory.
Rajion Neal rumbled for a pair of touchdowns in the losing effort.
Brandon Hill had three catches for 85 yards and pair of interceptions, one of which he returned 65 yards for a touchdown as West Lowndes won 26-0 over East Oktibbeha.
West Lowndes can now claim the Oktibehha County championship after back to back wins over both West and East Oktibbeha.
Malcolm Johnson had a 48 yard catch and run for a score as Northridge won their season opener 34-6 over Holt.
Kaleb Eulls and Yazoo County got back on track with a solid defensive effort in a 14-0 win over Kosciusko. A late fumble recovery in the end zone put the game out of reach.
Blaine Clausell helped lead the charge in a 359 yard rushing effort for Baker High, but in the end the robust running game was not enough. Baldwin County dropped Baker to 0-1 with a 55-40 win.
Earlier this week Rashod Henry had a good game in limited action as the Wildcats of Pearl River trounced Holmes 45-7.
Other scores of note:
Junior standout quarterback Mikhail Miller threw two touchdown passes and ran for another as IAHS slammed Amory 49-7.
Asian Ruff capped the scoring for the Indians with a 35 yard pick six.
It was the Nick Griffin show last night for Perry Central. Griffin reached the end zone four times last night including three rushing touchdowns in a 35-20 win over Columbia.
Dylan Favre set a new single game state record for passing yards with 549 on 32 of 50 as the Rock-a-chaws routed Mendenhall 50-7.