Undefeated at home this season, the Spartans (24-5, 13-3 Big Ten) lead No. 8 Ohio State by 1 1/2 games and No. 11 Michigan by two games in the conference race with three games left in the regular season. The Buckeyes, who close the regular season at Michigan State, can pull back within a game by beating Wisconsin at home Sunday.
The last-place Cornhuskers (12-15, 4-11) have lost five of six.
Michigan State, which led by eight at halftime, turned the game into a rout early in the second half with a 13-0 run that put the Spartans ahead 38-17.