NC State fell to 4-4 (1-3 ACC) with the loss, while the Seminoles climbed to 5-3 (3-2 ACC).
Manuel sizzled in the first half, completing 17 of 22 for 212 yards and the touchdown throw to Shaw that gave Florida State its 24-0 halftime lead. His lone interception came when Rodney Smith bobbled the ball and had it swiped away by Terrell Manning.
Lonnie Pryor dragged a handful of NC State defenders into the end zone midway through the second quarter to give the Seminoles a 17-0 lead.
Devonta Freeman scored on a 7-yard run for the game's first touchdown and Dustin Hopkins added a 43-yard field goal. A 32-yard Manuel pass to Christian Green preceded Freeman's scoring run. The two-play scoring drive was set up by Greg Reid's 28-yard punt return.
NC State came into the game averaging 31.4 points and 370.6 yards offense, but struggled all day to slow down Florida State's speedy defense. The Wolfpack's deepest penetration of the game was at Florida State's 28 and that was the benefit of a penalty.
Glennon, who had thrown for 1,717 yards and 19 TD's coming into the game, completed 19 of 34 passes for 130 yards while James Washington was held to 35 yards on 13 carries.
T.J. Graham, who came into the game leading the nation in all-purpose yards, picked up 76 of his 116 yards on kickoff returns.
It was the first time since a 34-0 loss to South Carolina in the 2008 opener that the Wolfpack was kept off the scoreboard.