Bernard James had 12 points while Okaro White and Michael Snaer each finished with 10 for the Seminoles (19-7, 10-2 Atlantic Coast Conference).
They never trailed, shot 49 percent, led by double figures for the entire second half, held N.C. State to 29 percent shooting -- its worst of the season, by far -- and forced 17 turnovers.
That helped Florida State win its third straight, remain atop the league standings and improve to 4-0 against the Tobacco Road schools in North Carolina -- the first time it has beaten all four in the same season.
C.J. Leslie scored 21 points to lead the Wolfpack (18-9, 7-5), but the rest of the team combined to shoot 9 of 44 in their second straight loss.