The Wolfpack clinched the No. 5 seed in the ACC tournament Thursday in Atlanta.
Virginia Tech (15-16, 4-12) lost its fourth straight and will be the No. 10 seed in the conference tournament.
N.C. State trailed early, but used a 16-2 run midway through the first half to take the lead for good. In the second half, the Hokies cut the Wolfpack lead to 51-47 on an Erick Green jumper with 10:30 remaining. But N.C. State answered with an 11-0 run and never looked back.
Cadarian Raines led the Hokies with 15 points, and Dorian Finney-Smith added 11.