Right fielder Jake Fincher got things going for NC State (45-14) in the bottom of the first inning with a one-out single through the left side. Two batters later, first baseman Tarran Senay launched his seventh home run of the season over the right-centerfield wall to give the Wolfpack an early 2-0 lead over the Bearcats.
Binghamton (30-24) pushed a run across in the top of the second inning to cut the NC State lead in half. After allowing the home run to Senay, the Bearcats' starting pitcher, Jack Rogalla (5-5), retired 12 of the Pack's 14 subsequent batters, but Wolfpack shortstop Trea Turner crushed a solo home run to left field to lead off the bottom of the sixth inning and give NC State a 3-1 lead.
Turner's homer marked the first time the Wolfpack homered twice in a game since its 12-6 win over Wake Forest on March 15 – a span of 39 games. State had 15 home runs in its first 19 games this season, and just nine over the course of the next 39 contests.
With one out in the bottom of the seventh inning, centerfielder Brett Williams singled, before designated hitter Jake Armstrong was hit by a pitch to put runners on first and second. Second baseman Logan Ratledge followed up with a hard-hit RBI single to left to increase the Wolfpack's lead to 4-1.
Fincher, Senay and Brett Austin all went 2-for-4 to lead a 9-hit attack for the Wolfpack.
Leadoff hitter Zach Blanden had three singles to pace the Bearcats.
NC State will take on William & Mary on Saturday at 7 p.m., while Binghamton will face Ole Miss at 2 p.m.
The third-seeded Tribe upended the Rebels, 4-2, in the opening game of the regional on Friday afternoon.