Caleb Martin and Maverick Rowan added 15 points apiece for NC State (2-1), who never trailed. Abdul-Malik Abu had 14 points and nine rebounds. The Wolfpack outrebounded the Jaguars 52-37 but struggled from the free throw line, making just 23 of 39 (59 percent).
NC State raced out to a 10-2 lead with two baskets by Barber and never looked back. The Wolfpack stretched their lead to 50-34 early in the second half after a jumper by Barber and a 3-pointer by Rowan.
Matt O'Leary scored 17 points to lead IUPUI (1-2), which got outscored 32-12 in the paint. Mason Archie II added 11 points.
The Jaguars scored on five consecutive possessions to cut the deficit to 56-47 midway through the second half, but never got closer.
N.C. State led 38-27 at halftime, maintaining the cushion it built in the game's opening minutes.
O'Leary kept the Jaguars in it with a hot stretch midway through the first half. He made three 3-pointers in a four-minute span, cutting N.C. State's lead to 30-25 with 5:20 remaining.
After a timeout by coach Mark Gottfried, the Wolfpack answered with an 8-2 spurt. Rowan hit a 3-pointer from the left corner, and Barber made a pair of free throws to close the half.
Darell Combs led IUPUI in scoring in the team's first two games, but he struggled against a defense that was loaded up to stop him. Combs had just five points on 1-of-11 shooting.
IUPUI was called for 34 fouls compared with 17 on N.C. State. Three IUPUI players fouled out, and four more finished with four fouls.