Wilson, a first-team All-ACC performer, suffered a tear of his posterior cruciate ligament late in the second quarter and did not return to action after halftime. He had passed for 186 yards and a touchdown and rushed for 46 yards prior to the injury.
The injury will not require surgery. Instead, Wilson will be confined to several weeks of limited activities, followed by functional rehabilitation.
Wilson, the 2008 ACC Rookie of the Year, finished the season with a streak of 249 passes without an interception, the longest active streak in the nation.