Manuel sprained his ankle on February 27 and was unable to play in Sunday evening's win at NC State.
Felton was injured late in the game as he fell to the floor after being fouled bringing the ball upcourt in the final minutes of the game.
Roy Williams said during this week's ACC conference call that he expects Manuel to play.
"I think he'll be able to play [against Clemson]," Williams said. "It was close yesterday and I think he will be ready to play. A lot remains to be seen as to how much improvement he does get. After the game yesterday he felt like he'd be ready to play Tuesday, so that's what we're basing it on."