Drew Crawford hit four 3-pointers and scored all 14 of his points as the Wildcats (7-0) rolled up 59 points before the break, the most Northwestern has scored in a half in coach Bill Carmody's 12 seasons. Northwestern's lead peaked at 41.
The Wildcats tied the school record for 3-pointers in a game, hitting 20. They also made 20 against North Carolina AT&T on Dec. 13, 2009.
The game was lopsided in every respect. Northwestern's John Shurna, whose 21.8-point scoring average entering the game was the highest of any player in a BCS conference, hit three first-half 3-pointers but didn't play in the second half and finished with nine points.
Paul Crosby led Mississippi Valley State (1-7) with 23 points.