The Irish (6-1) took a 51-32 lead into the break, thanks largely to their blistering accuracy from 3-point land. They hit 10 of 16 3-point attempts in the first half, a 62.5-percent clip.
Grant hit a strong baseline drive and drew a foul, then made the free throw, to give Notre Dame its then-biggest lead, 42-27, with 3:20 to go in the half. Moments later, he stole an inbound pass near the top of the Chicago State key and drove the length of the floor for an electrifying windmill dunk.
Clarke Rosenberg led the Cougars (1-6) with 16 points.