The loss dropped Notre Dame from a double bye and No. 4 seed in this week's conference tournament to the sixth spot. The Irish will begin play Wednesday night vs. the winner of the Rutgers/DePaul game to be played Tuesday afternoon.
Notre Dame beat DePaul twice this season, both in overtime. The Irish held off Rutgers at home in January, 69-66, surviving a furious rally by the Scarlet Knights in the process.
Should Notre Dame win its Wednesday night game, the Irish would move on to face No. 3 seed Marquette on Thursday night. The game will be the first for the Golden Eagles thanks to a double bye and automatic berth in the quarterfinals.
Winner of that quarterfinals contest feeds into No. 2 Louisville's bracket, though the Cardinals must first contend with either Villanova (No. 7 seed) or St. John's (No 10), a game played Wednesday prior to Notre Dame's 9 p.m. (ET) tip.
Notre Dame cannot face No. 1 seed Georgetown, No. 4 seed Pittsburgh, or No. 5 seed Syracuse without reaching the Big East Championship game played Saturday night.