The Irish won the first game of the series on Friday night, but had to delay the start of the final two games to Monday due to weather.
Dan Kapala pitched the first game going the distance for the Irish leading Notre Dame to a 9-4 victory.
Kapala logged seven innings, allowing four runs on eight hits, while striking out three.
The Irish scored nine runs on eight hits in a very efficient day at the plate.
Sophomore Sean Gaston broke the game open with a three-run homer in the bottom of the third to put the game out of reach.
Gaston finished 2-for-3 with four RBI on the day.
The second game featured Wade Korpi on the mound. The freshman lasted just one inning as he allowed one run on three hits.
The Irish were deadlocked at 4-4 until the top of the seventh when Villanova plated two runs on some costly mental mistakes by the Irish. Villanova added another run in the top of the eighth to build a 7-4 lead over Notre Dame.
But junior Greg Lopez came up in the bottom of the ninth and hit a three-run shot to tie the game for the Irish and send it into extra innings.
Doherty closed out the top of the 10th, and the Irish loaded the bases in the bottom of the inning, but they just could not push across another run and the game ended in a 7-7 tie.
"Tying a game is a very distasteful feeling," said Irish coach Paul Mainieri after the game. "I guess you have to take some satisfaction in the way we came back in the ninth."
Alex Netty (3-for-6), Matt Edwards (3-for-5, R, 3 RBI) and Greg Lopez (3-for-5, HR, R, 3 RBI) led the Irish at the plate in the second game, but Notre Dame just couldn't come up with the key hit to break the game open in the 10th.
"I kept waiting for that one big hit," said Mainieri. "In the second game, we just didn't get a lot of big hits."
Notre Dame (24-15-1) moved into second place in the Big East standings with their solid weekend of play and will take the rest of the week off before returning to Frank Eck Stadium for a two-game series against Cleveland State starting on Friday.