After using a three-run rally in the bottom of the seventh to tie it, Notre Dame lost its game against Oakland 6-5 at Frank Eck Stadium on Wednesday night.
Notre Dame falls to 14-8 on the season while the Golden Grizzlies jump to 6-11.
But Oakland used a one-out walk from Brett Geschke to start its game-winning rally in the eighth. Geschke was replaced by pinch runner Tim Ryan, who stole second and third before scoring on a two-out hit from D.J. Jarrad.
The Irish had a chance in the eighth, but Ryan Connolly was thrown out trying to steal third and Notre Dame never had another runner in scoring position.
Notre Dame starter Steve Sabatino allowed three runs and four hits in four innings while reliever Joe Spano gave up three runs (two earned) in 3.2 innings and was tagged with the loss.
Oakland starter Greg Welke was solid until he ran into trouble in the seventh. Welke allowed five runs (four earned) in 6.2 innings and did not factor in the decision as reliever Andrew Estes picked up the victory.
The game was tied 1-1 after two innings before Oakland scored twice in the third and twice in the fifth. David Casey reached on a double in Notre Dame's half of the sixth inning and scored on Greg Sherry's RBI groundout.
Grosso and Casey were the only multiple hitters for the Irish and each had two hits and scored a run.
The Irish resume Big East Conference play this weekend with a three-game series at Pittsburgh.