Pittsburgh got three-run homers from Joe Leonard and Nathan Hood in a 15-7 win over visiting Notre Dame on Saturday afternoon.
The loss drops the Irish to 15-9 overall and 2-3 in the Big East while the Panthers jump to 14-7 overall and 3-2 in the conference.
Notre Dame's Dustin Ispas struggled in his first career conference start as he was tagged for five runs and six hits in just 2.1 innings of work. Relievers Will Hudgins and Steven Mazur also struggled and allowed 10 runs in 4.2 innings combined.
Greg Sherry led the Notre Dame offense with three hits, two runs and a run batted in. David Casey, Mick Doyle and A.J. Pollock had two hits apiece while Matt Scioscia added a two-run homer in the ninth, but it was not nearly enough.
Pittsburgh jumped out to a 5-1 lead after three innings and when Notre Dame scored three in the fourth to make it a one-run game, the Panthers put up four in the fourth, led by Hood's two-out, three-run blast. Pittsburgh added two in the sixth and put up four more in the seventh when Leonard launched his homer.
Eric Maust will start for the Irish when they finish their series with a 12:00 game on Sunday.