Pittsburgh took a commanding lead before having to off hold Notre Dame as the Irish tried to mount a comeback and the host Panthers held on for a 14-11 victory on Sunday.
For the Irish, it was the second straight Big East weekend series that saw them take the opening game only to lose the next two. Notre Dame falls to 15-10 overall and 2-4 in the Big East while the Panthers improved to 15-7 overall and 4-2 in the league.
Pittsburgh got home runs from Chris Sedon, Morgan Kielty and Nathan Hood.
Notre Dame took a 2-0 lead in the first after Golden Tate led off with a single before Pollock homered. The Panthers tied it up with two in their half of the first before Intlekofer launched a solo homer to put the Irish back on top in the second.
The Irish held onto that lead for just one inning before things fell apart in the third. Pittsburgh's Hood blasted a three-run homer for the second straight day as Pitt used nine hits and two Notre Dame errors to score seven times in the frame and take a 9-3 lead.
McConnell had a RBI triple for Notre Dame in the fourth and came home on an Intlekofer single before Pollock scored on a Barnes groundout in the fifth to cut the lead to 9-6.
But the Panthers came back with four of their own in the fifth, led by a two-run homer from Kielty, to increase their lead to 13-6.
Intlekofer scored on a David Mills sacrifice fly in the sixth and Barnes launched a solo homer in the seventh to make the score 13-8.
Pittsburgh got one back in the seventh before the Irish mounted their last charge when McConnell smacked a three-run home run in the top of the ninth to make it a three-run ballgame. But Pittsburgh's Joe Leonard faced the potential tying runs in Barnes and Matt Scioscia and retired both of them to end the game.
Notre Dame will be back in action for a pair of non-conference home games this week. The Irish will host Michigan State on Tuesday and Toledo on Wednesday.