Golden Tate made his first career collegiate home run a memorable one.
Tate lined a 2-2 fastball over the fence in left field in the top of the ninth as the Irish pulled off a wild 13-12 come-from-behind victory in the final game of a weekend series at Louisville.
The Irish, who lost a chance at a similar comeback victory on Friday before beating the Cardinals on Saturday, jump to 25-16 overall and 10-8 in the Big East while Louisville falls to 29-13 overall and 12-6 in the league.
Neither team's starter had memorable outings as Notre Dame's Eric Maust was touched for five runs in two innings of work while Louisville starter Bob Revesz allowed four runs in three innings.
The game was tied 7-7 after four innings, but Louisville opened up a 12-7 lead with five runs on seven hits in the bottom of the fifth.
Notre Dame took advantage of a pair of walks and hit batter in the top of the seventh. The Irish had just two hits in the frame, but one of them was David Casey's two-out grand slam that scored Jeremy Barnes, Tate and A.J. Pollock to tie the game.
The only other hit in the game after Casey's grand slam was Tate's two-out solo shot to win it.
Notre Dame's Ryan Richter pitched three innings of scoreless, hitless relief to pick up the win. Will Hudgins came on in the ninth and walked the first batter he faced before sitting down the next three in order to earn the save.
Casey finished with a career-high five RBI while Mick Doyle and Greg Sherry led the Irish with three hits apiece. Doyle also knocked in three while Sherry, Pollock and Tate each scored three times.