Karageorge, a 6-4, 273-pound senior from Columbus, was last seen in a black hooded sweatshirt, black sweatpants and a black knit hat.
Also a member of the Ohio State wrestling team as a heavyweight, Karageorge joined the Buckeye football team in August.
"Our thoughts continue to be with the family of Kosta Karageorge and we pray that he is safe and that he is found soon," Ohio State head coach Urban Meyer said in a statement. "He is a young man who joined the football team in August and was a hard worker on the field and pleasant off the field. He has been an important player in practice for us, right up until the time he was reported missing. If anyone knows anything about his whereabouts, please help his family and contact the authorities.”
Meyer also urged the crowd at Friday's Beat Michigan Tailgate to keep Karageorge and his family in their thoughts and prayers.
In other interviews done by his family, there were indications that he was suffering from the effect of concussions suffered during his athletics career.
“First and foremost, our primary concern is for the health, safety and welfare of Kosta," team physician Dr. Jim Borchers said. "While we are not able to discuss or comment about the medical care regarding our student-athletes, we are confident in our medical procedures and policies to return athletes to participation following injury or illness.”
If anyone has any information on Karageorge's whereabouts, they are asked to call Ohio State University Police at 614-292-2121.