The combined total of 72 points was the most scored in the 59-year history of this all-star game.
Ten future Buckeyes played in the game, including seven on the victorious South squad.
Game MVP honors went to South wide receiver Ro Grigsby, who had seven catches for 177 yards and three touchdowns.
"I knew if I worked hard I could go out and have a good game," said Grigsby, a Clayton Northmont product headed to Kansas State. "But you don't expect something like this. You just hope for the best."
The South offensive MVP was quarterback Grant Gregory from Athens. He was 9 of 16 passing for 202 yards with two touchdowns. He also had an 80-yard TD run.
"We head to step our game because their line was so good," Barrow said. "It's a real honor to win this award. It feels great."
The North offensive MVP was Austintown Fitch wide receiver Miles Williams, who tallied four catches for 129 yards and a touchdown. Williams originally committed to Ohio State, but ended up signing with Michigan State after his offer to OSU was revoked in January.
The North defensive MVP was Cleveland Glenville defensive end Curtis Terry, an Ohio State signee. He tallied two sacks.
"I was happy," said Terry, who was a late addition to the North squad. "I had a great time out there tonight. That was a lot of fun. There were a lot of great players out here."
Among other OSU performers in the game, South running back Erik Haw of Columbus Independence finished with 88 yards on 14 carries with two touchdowns. One of his carries was a 48-yarder.
"This was a good experience to be out here with the best players in high school," Haw said.
"They were going to make some big plays and we were going to make some big plays," said Underwood, a defensive back from Hamilton. "(South coach Steve) Channell talked about it all week. The key was going to be how we reacted to their big plays. We reacted in a positive way.
"In the second half, Coach Channell told us to come out and get after it."
Skeete, who signed a scholarship letter for Ohio State this week, opened the scoring with a 32-yard field goal, putting the South up 3-0 with 6:53 left in the first quarter.
The North answered as Thom Abbott was flushed from the pocket and threw deep to Williams, who got behind Welch at the South 10 and hauled in a 47-yard TD pass for a 7-3 North lead with 5:14 left in the first quarter.
The teams then combined to score three touchdowns in 45 seconds of clock time. The barrage began as Gregory was flushed and just started running. He took off toward the right sideline, turned the corner, got a block from Durell Williams and was gone on his 80-yard TD run to put the South up 10-7 with 39 seconds left in the first.
Abbott then took a handoff on an end around and hit Williams for a 61-yard gain, setting up an 11-yard TD run by Edwin Hood to put the North up 14-10 with eight seconds left in the first quarter.
The South then regained the lead as Gregory hit Gary Russell for a 52-yard gain on a screen, setting up a 17-yard slant pass to Grigsby for a touchdown and a 17-14 South lead with 11:55 left in the first half.
The South used some trickery of his own as Nick Moore took a lateral pass and threw a 48-yard TD pass to Grigsby for a 24-14 lead with 6:28 left in the half.
The North answered with a 63-yard TD pass from Clint Cochran to Asante White, cutting the South lead to 24-21 with 4:50 left in the half.
But the South extended the lead back up to 30-21 with 1:50 left in the half as Gregory found Grigsby for a 28-yard TD pass. Skeete's PAT kick was blocked.
The North came out on the first possession of the second half and scored as Brian Hoyer hit White on an 11-yard slant, cutting the gap to 30-28 with 8:09 left in the third.
But the South answered with a 13-play, 80-yard drive. Haw opened the drive with his 48-yard run. He carried eight times for 58 yards on the drive, capping it with a 1-yard plunge to put the South up 37-28 with 36 seconds left in the third.
The South capped the scoring with Haw's 3-yard touchdown run with 4:13 left. That was set up by a 51-yard punt return by Adam Blevins.
The South has won three of the four games played since the series was moved to Crew Stadium, closing the all-time gap that North leads to 32-24-3.