Tucker, a Cleveland native who played high school ball at Cleveland Heights, had coached with Ohio State for four years and had previously been defensive backs coach at LSU in 2000 and Miami (Ohio) from 1998-99.
"Coaching at Ohio State has been an unbelievable experience, and I will always have a special place in my heart for the Buckeyes and our national championship team," Tucker said.
Tucker is viewed as a rising star in the coaching profession and had also gained a reputation as one of Ohio State's top recruiters.
"I am excited about the addition of Mel Tucker to our staff," new Cleveland Browns head coach Romeo Crennel said in a press release from the Browns. "He is a sharp young coach and I was very impressed with him during our interview. As evidenced by the job he has done with the defensive backs at Ohio State, I know he will be a great contributor to our defense and he will be instrumental in the success of our defensive backs."
Tucker, who had recruited the Cleveland area, had become one of Ohio State's most popular assistants among both players and high school coaches. No word yet on who will replace Tucker at Ohio State.