That duo combined for 46 points as the third-ranked Tigers cruised to a 64-48 win over No. 4 Ohio State before 8,499 at Value City Arena in a highly anticipated match-up of top-five teams.
Fowles tallied a career-high 25 points and 16 rebounds, going 11 of 15 from the floor. Augustus was just as dangerous. She scored six of her 21 points during a 13-point first-half run that gave the Tigers (6-0) an almost insurmountable 33-15 halftime lead over the Buckeyes (6-1).
OSU missed 15 of its last 16 shots in the first half and ended up hitting just 33.3 percent of its shots (19 of 57) for the game.
OSU, which got 14 points from Jessica Davenport and 13 from Brandie Hoskins, trimmed the lead to 12 points at 44-32 on a three-pointer by Stephanie Blanton with 12:01 left. But the Buckeyes could draw no closer.
"I think we started to rush things and played a little too fast of a tempo," said OSU coach Jim Foster. "It was difficult to find Jessica (Davenport). Tonight, LSU was a much better basketball team than us.
"It was obvious that we have a greater chance to improve. The goal objective is to make Jessica (Davenport) and Brandie (Hoskins) of Seimone Augustus' and Sylvia Fowles' level. There is a competitiveness and toughness of that basketball team (LSU) that we don't have now. We'll try to grow from this game because it was a reality check."
LSU got the lead as high as 25 with four minutes left.
Blanton, Marscilla Packer and Debbie Merrill each had seven points for OSU, which saw its 21-game home winning streak snapped.
The Buckeyes came in leading the nation in defense, allowing just over 40 points a game, and were first in scoring margin at 38.4 points per game.
It was the fourth meeting between the teams but the first since 1990. LSU has won three of the four matchups.
OSU hosts Sacred Heart next Tuesday and Canisius next Thursday.