Davenport, the reigning Big Ten player of the year, scored a season-high 34 points, grabbed 16 rebounds and had six assists to help No. 8 Ohio State past host Iowa 72-62.
That performance followed Davenport's game-winning shot on Monday night against Oklahoma. The win was OSU's sixth victory in seven games.
Davenport, who also had three blocked shots, was 14 of 22 from the floor and 6 of 7 at the foul line for Ohio State (12-2, 3-1 Big Ten).
Debbie Merrill added 15 points for Ohio State, which never trailed. Led by Davenport's seventh double-double of the season, Ohio State outrebounded Iowa 39-30 and outscored the Hawkeyes 52-30 in the paint.
Crystal Smith led the Hawkeyes (10-6, 3-2) with 26 points and Ohio native Megan Skouby added 11.
Iowa trailed by as many as 16 points before staging a rally midway through the second half. The Hawkeyes went on a 21-11 run and got within 55-49 on a 3-pointer by Smith with 11:22 left.
The teams traded baskets for the next 5 minutes before Davenport converted a three-point play with 6:00 left to push Ohio State's lead to 66-55.
Iowa - which upset No. 9 Michigan State on Monday - never got closer than 68-59 after that.
Davenport scored the Buckeyes' last nine points.
Davenport broke the game open with 11 straight points during a 15-1 run midway through the first half that gave the Buckeyes a 39-21 lead. Iowa was unable to stop Davenport from establishing position inside, and she took advantage with five baskets from inside 10 feet during a 3:33 span.
Ohio State returns home to host Michigan at noon Sunday. That will be the first half of a Sunday twin-bill with the OSU men's team, which hosts Michigan State at 4:30 p.m. Fans will need separate tickets for both games. Value City Arena will be cleared after the women's game and gates will open for the men's game at 3 p.m.