Todd Boeckman had a solid first half as the Buckeyes built a 17-0 halftime lead.
Tight end Jake Ballard dove into the end zone for the Buckeyes' first touchdown.
Linebacker James Laurinaitis had 12 tackles to lead the OSU defense.
Freshman Cameron Heyward (97) helped pressure MSU quarterback Brian Hoyer (7) throughout the game.
Chris "Beanie" Wells starred in the game, rushing for over 200 yards.
Wells even introduced MSU's T.J. Williams (12) to his stiffarm move.
At halftime, Archie Griffin was on hand to honor former OSU quarterback Rex Kern for his induction into the College Football Hall of Fame.
Brian Robiskie caught a second-half touchdown to make it 24-0.
Vernon Gholston showed his strength against MSU's Peter Clifford (75).
Marcus Freeman (1) and Malcolm Jenkins (2) helped slow Michigan State running back Javon Ringer.
Mark Dantonio fell to 0-3 as head coach vs. Ohio State.