The 18th-ranked Buckeyes improved to 7-2 with a strong defensive effort the helped them overcome their own shooting woes at Nebraska.
The Cornhuskers (6-2) led 36-26 at the half but shot just 24.1 percent (7 for 29) in the second half. The Buckeyes, meanwhile, hit 14 of 28 field goals and outscored their hosts 43-29 after the break.
Overall, Ohio State shot 41.4 percent (24 for 58) and made 7 of 15 threes (46.7 percent).
Jantel Lavender had 20 points and 10 rebounds, giving her nine double-doubles in as many games this season, and Ashlee Trebilcock made 4 of 5 three-pointers en route to 14 points. Brittany Johnson (11 points) was the third Buckeye in double figures. She made a pair of treys. Andrea Walker grabbed 11 rebounds and blocked two shots before fouling out.
Buckeye point guard Samantha Prahalis struggled with her shooting for a second straight game, missing both her three-point attempts and 6 of her 8 field goals overall, but handed out eight assists and nabbed five steals. She also had seven turnovers and fouled out in 34 minutes.
She was 3 for 13 in a 72-63 home loss to No. 2 North Carolina on Wednesday night.
With the win, the Buckeyes broke a two-all tie in the all-time series between the schools. Ohio State beat Nebraska 86-74 in Columbus last season.
After playing nine games in the season's first 23 days, the Buckeyes will get more than a week off before returning to the court. They play host to Cleveland State (4-4) at Value City Arena in Columbus at 7 p.m. Dec. 15.