The loss comes just three days after OSU suffered a 71-48 defeat to Texas A&M, while making just one of its final 17 shots during the game's final 15 minutes of play.
OSU had made just six three-pointers in its first two Big 12 games but back-to-back treys from Ray Penn and Keiton Page (the team's sixth and seventh of the game) gave the Cowboys a 54-42 lead with 16 minutes remaining. But the Cowboys would score just four points over the next 10 minutes, and the Buffaloes went on an 18-4 run to take the lead.
The Cowboys regained their last lead of the game on Page's three from the top of the key but the Buffaloes made their free throws down the stretch – scoring 13 of their final 15 points from the charity stripe – for the victory in front of the sold-out crowd of 11,0906 at the Coors Event Center.
Colorado was outstanding at the free-throw line, making 34 of 39 (including leading scorers Cory Higgins and Alec Burks combining for 21 of 22). The Buffaloes outscored the Cowboys by 23 at the line. Higgins led all scorers with 23 points, while Burks had the second double-double of his career (20 points, 11 rebounds).
Jean-Paul Olukemi, Keiton Page and Marshall Moses combined to score 54 of the Cowboys 71 points. Olukemi, who made the first start of his OSU playing career, led the way with 21 points, while Page added 19 and Moses 14.
Colorado shot just 37.5 percent from the field for the game but the Buffaloes were 11 of 21 shooting (52.4 percent) in the second half. OSU shot 47.3 percent for the game, but was outrebounded 39-24.
Oklahoma State returns home Wednesday night to face Iowa State at Gallagher-Iba Arena.