Griffin has been an undeniable star throughout his Baylor career but if there is one team he has experienced no success against it's the Oklahoma State Cowboys.
Griffin has faced OSU on two prior occasions — he didn't play OSU in 2009 because of an injury — and they turned out to be tied for the third and fourth worst losses of his career.
In fact, the electric Griffin has never scored a touchdown against OSU through the air or on the ground.
Last season, OSU held Griffin to 30-of-48 passing for 267 yards with zero touchdowns and a pick. He also was held to 15 rushing yards on 1.7 yards per carry. Brandon Weeden had 19 rushing yards in the Pokes' 55-28 win.
As a freshman in 2008, Griffin led his Bears into Stillwater as a freshman and was handed a 34-6 defeat. He went 15-for-27 for 162 yards with no scores and no picks. He was also controlled in the rushing game, gaining just 12 yards on 12 carries.
This week Baylor returns to Stillwater for Griffin's third shot at the Pokes in Boone Pickens Stadium, thanks to scheduling changes because of conference realignment, and the No. 3 Cowboys are looking forward to the opportunity.
"It's fun actually because it's very challenging," defensive tackle Christian Littlehead said. "That's what defensive linemen always talk about is getting sacks, and that's one person you'd like to sack, a big-name quarterback like that. That's what's going to be fun - going against him. But even just containing him and getting turnovers, we did it last year and that's what really helped us."
Even with prior successes against RG3, the Pokes have a tremendous amount of respect for him as a runner and as a passer, but coach Gundy said on Monday that one concerns them more than the other in preparation.
"Passer. He's doesn't run the ball very much - he can. If you look at his career, he's gotten away from that because he's become such a good thrower," Gundy said. "(Griffin's) numbers speak for themselves. When you can perform in as many games as he has, it speaks for itself. His quarterback rating and his completion percentage - he went through five weeks where he had more touchdown passes than incompletions, I think that's correct. His numbers speak for themselves."
Defensive coordinator Bill Young seconded Gundy's remarks and said Griffin is easily the most polished of any dual-threat quarterback his defense has faced this season.
"If you look at the Heisman Trophy race, he's right in the thick of it," Young said. "The other two quarterbacks (David Ash and James Franklin) were young quarterbacks. They're going to be great down the road, but they're freshmen and sophomores and haven't really had the action Griffin has."
While Griffin is a bigger threat, it could prove fortuitous for the Cowboys to have faced dual-threat quarterbacks in consecutive weeks leading up to Baylor.
"It is a benefit. They run the same plays," Young said. "They have very, very similar offenses and we've had some issues with some of those plays, and we've had to get right on it this week and make sure we make some corrections to make ourselves a little better position to make some plays."
The bad news for Griffin and the Baylor offense is that the Pokes won't be overlooking them because of past success and a huge matchup next week against Kansas State because this defense has a chip on its shoulder.
The defense has faced nation-wide ridicule and has been described as the weak link that could prevent OSU from winning the Big 12 or reaching the national title game despite leading the nation in turnover ratio and being tied for the Big 12's best scoring defense in conference play.
OSU's defenders are sick of the doubters and shutting down a Heisman hopeful could be just what the defense needs to quiet the critics.
"It always burns us up. We always talk about not being a weak defense," linebacker Joe Mitchell said. "We want to establish our name. It is always good to have a powerful offense but we want to make a name for ourselves as well."