The Cowboys claimed the series with the victory and improved to 26-14 overall and 7-7 in Big 12 play, while the Tigers fell to 27-8 and 8-3 in league action.
Thomas Cowley (8-2) allowed four runs on nine hits in seven innings to pick up the win, while Scott Richmond pitched a perfect final 1.2 innings to earn his fourth save of the year.
Adam Carr's RBI single in the first gave OSU an early 1-0 lead. The Pokes scored three runs in the third to extend the advantage to 4-0. Corey Brown had a RBI single and Carr a sacrifice fly RBI to lead the way.
Missouri third baseman John McKee's solo homer in the fourth opened the scoring for the Tigers. They added two more runs in the sixth on a RBI double by Jacob Priday and a RBI single by Greg O'Neill to cut the lead to 4-3.
Adam Carr walked to lead off the sixth and advanced to second on Rusty Ryal's sacrifice bunt. Jeff Parrish then fouled out setting up Ptak's homer to left-center, his third round-tripper of the year.
The Tigers added a run in the eighth to cut the lead to 6-4, but Richmond was able to get out of a one-out two men on situation to preserve the lead.
Nathan Culp (6-1) was charged with his first loss of the year after giving up six runs, five earned, on seven hits in seven innings of work. Jacob Priday led the Tiger offense with a 3-for-4 day at the plate, while John McKee and James Boone aided the cause with two hits each.
Jeff Parrish was the lone Cowboy with two hits on the day while six other starters contributed with a hit each.
The teams will close out the series Sunday at 1 p.m. Missouri will throw righthander Doug Mathis, while Oklahoma State's starter is still to be determined.
Ptak's Homer Leads Cowboys Over Tigers
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