"I've waited so long for this and the day is finally here," Bryant said. "I can't wait to get out there and show that I can make a difference. I used to dream about this as a kid and it still feels like it's a dream.
"I'm so excited. It's a blessing from God," added Bryant.
Bryant only played in three games his junior season before being ruled ineligible by the NCAA but still ranked among the top receivers in school history. He is third all-time in touchdown catches (29), fourth in both career receptions (147) and receiving yards (2,425), and 12th on the all-time scoring list (194 career points).
"Going to Oklahoma State was the best thing to ever happen to me," said Bryant, who earned All-America honors as a sophomore after catching 87 passes for 1,480 yards and 19 touchdowns.
"I had a great experience there because of my teammates and coaches, the fans and really everyone there. It's a great place and I'll always be a Cowboy," Bryant added.
Oklahoma State head coach Mike Gundy said, "We're all happy and excited for Dez. He's been through a lot and it will be good for him to get back on the football field with his teammates. He is a special player with a bright future ahead of him in the NFL."
Bryant becomes the third wide receiver in OSU history to be selected in the first round, joining Hart Lee Dykes (1989, 16th overall by the New England Patriots) and Rashuan Woods (2004, 31st overall by San Francisco).