It was an 11-0 Texas A&M run to start the final 20 minutes that helped the Aggies build a sizable enough lead to put them in commanding position.
After OU led 26-25 at intermission, Texas A&M used that spurt to go up 36-26.
The Sooners used a mini run of their own, scoring eight of the game's next 10 points to cut the deficit to just four.
But from that point on, the Aggies dominated.
In a matter of minutes, Texas A&M again led by double digits, and the contest was, quite frankly, not a contest from there on in.
Texas A&M led by as much as 15 on three different occasions in the second half.
The beginning of the game was a much different story, however, than the second half.
Teams traded the lead seven times and were tied five times in the opening frame.
OU even led 18-13 just more than 10 minutes in.
However, a 6:52 Sooner drought allowed the Aggies to come back, and after that, the Sooners led just twice, including their halftime advantage.
Guard Cade Davis was the only OU player in double figures, as he managed nearly half the team's offensive production with 21 points on 7-for-16 shooting.
He was 4-for-7 from the free throw line and also brought down a team-high seven rebounds.
The Sooners (12-15, 4-9 Big 12) next return home to the Lloyd Noble Center for a battle against No. 2 Kansas at 3 p.m. Saturday.