One that will be called upon to relieve a large portion of those duties is sophomore running back Roy Finch.
But until he can do so, he must completely regain his health.
Finch was sidelined for the first five games of the 2010 season with a stress fracture in his left foot.
Over the next eight games, he impressed Sooner Nation with his elusiveness and instinctive abilities in the backfield, rushing for nearly 400 yards and a pair of touchdowns on 85 attempts.
But then he re-aggravated it in what doctors called a "recurrence of a stress fracture injury in his left foot" while preparing for the Fiesta Bowl.
That forced him to undergo surgery and the insertion of two pins in the foot.
"Yeah, you know, I had surgery probably about five, 10 weeks ago, I guess, 10 or 11 weeks ago," Finch said. "And it takes about that much time to fully kind of get back. So, I'm just--after I got off of the cast, I was, you know, on the field actually two weeks after, so it's [really fast] and I didn't have that much time."
Finch said hopes were to get him full strength by the start of spring ball, although that wasn't entirely the expectation.
"You know, when I had surgery they were like, ‘We're going to just see how you are and whenever spring ball starts,' Finch said. "It was kind of like 50-50. They didn't really know, and, you know, I kind of started running on it, but it wasn't 100 percent. It was still kind of aggravated, so they were like, ‘If you can run, we still want you back there doing it,' but I'm just trying to take it slow, and hopefully I can get back soon."
Attempting to get back to 100 percent, though, hasn't been all gravy.
In fact, it's been pretty grueling.
"Two or three rehabs a day, in between classes, after practice, just getting in there and just trying to do what I have to do," Finch said.
And that's even more reason to want to get back out there as soon as possible.
"Yeah, yeah, I'm just looking forward to that," Finch said.
One would figure, too, it would make it even that much more difficult just to have to watch teammates out there on the field while sidelined and trying to recover.
"It's not really, you know, that hard," Finch said. "I mean, I know I can play. I know what I can do. It's just taking me a little bit of time. You know, I'm just praying and just rehabbing and just doing what I need to do, trying to get back."
Certainly, the team and Sooner fans alike can't wait until the day when Finch bursts back onto the field full strength.