"It was good to come out and pleasing to play so well really," said OU head coach Bob Stoops.
And it was in large part because of a turnover show.
Nickelback Tony Jefferson recorded three second quarter interceptions, one of which was an acrobatic, one-handed, leaping snatch along the left boundary.
His other two came on tipped passes.
"Two of them I have to give up to my line by batting those balls down," Jefferson said. "I gave them their props, but I was just in the right spot at the right time. I appreciate my linemen, like I said, and it was fun having three picks today."
He had a fourth in his grasp, also in the second quarter, but it tipped off his hands and fell incomplete.
The Sooners turned all three of those picks into points.
Second, running back Dominique Whaley capped off a six play, 77-yard drive with a 1-yard touchdown run.
Then, Jones found Broyles for 27-yard touchdown pass, which made it 38-6 at the time after Jefferson's third INT.
"I mean, Tony did a great job; he played really well tonight and put us in a good position," Jones said. "I think just the way the offense came out executing and turning those turnovers into points, we did a really good job capitalizing on that and doing a good job of putting it in the end zone there."
Linebacker Tom Wort got in on the action in the third quarter when he returned a fumble 22 yards for a touchdown.
At that point, it was 59-6.
But as much as it was a turnover show, it was also the Dominique Whaley show for the second time this season.
Whaley gashed the Cardinals for a pair of touchdowns and 109 yards on 15 carries.
Those touchdowns were of one and 25 yards, both in the second quarter.
"I thought I did pretty well," Whaley said. "I had a couple busted assignments out there. But, I did pick up my blocks, and I blocked pretty well in pass protection, so I thought it was a pretty good night."
The Sooners struck first when Jones found tight end James Hanna for a 6-yard touchdown pass nearly five minutes into the game.
But that wasn't on the game's initial possession, although OU won the toss and elected to receive.
That's because Ball State successfully recovered an onside kick to start the game.
Nevertheless, OU struck first.
However, the Cardinals got on the board when place kicker Steven Schott converted a 34-yard field goal at the 6:59 mark of the first quarter.
Sooner place kicker Michael Hunnicutt hit one of his own when he put it off the left upright and through from 44 yards out, and it was 10-3.
Schott fired back from 31 yards out early in the second quarter, cutting the deficit to 10-6.
But Ball State wouldn't score again, and the Sooners would, a lot.
Fifty-two unanswered points, to be exact.
"This week was about us getting one week better," said co-offensive coordinator Josh Heupel. "Going out and performing the way we are capable of, which means you have to steer the right way."
First, it was Whaley's 25-yard score.
Then, Stills found the end zone, and Whaley scored again.
Broyles followed up with that 27-yard score, making it 38-6 at intermission.
The Sooners picked up in the second half right where they left off the first.
In fact, they scored 21 points in a span of 1:08 between the 12:42 and 11:34 mark of the third quarter.
First, Jones found a wide open Broyles in the middle of the field, and he streaked 64 yards to paint.
Exactly a minute later, on a busted coverage, Jones rifled it to wide receiver Jaz Reynolds, who sprinted 56 yards down the sideline for the score and 52-6 lead.
Reynolds, largely because of that one reception and another 62-yarder, led the team with his 141 receiving yards on five catches.
"I didn't know I led the team," Reynolds said. "But it is a good feeling I beat out Ryan. Ryan usually gets the most yards and touchdowns. I had my first touchdown today, and that was a good feeling."
That set the stage for Wort's fumble recovery on the very next play from scrimmage to wrap up the scoring flurry.
It was 59-6 before Hunnicutt made his second field goal of the night, this time from 37 yards early in the fourth quarter, and that wrapped up the scoring.
Jones finished with 425 yards and five touchdowns on 23-for-33 passing, although he threw an interception.
Broyles, who set the Big 12 Conference Receptions record in the contest when he picked up his 304th career reception in the third quarter, finished with a pair of touchdowns and 109 receiving yards on four catches.
"It feels good," Broyles said about shattering the record. "Hard work pays off. Playing with great athletes doesn't hurt either."
For Ball State, Wenning was just 12-of-31 for 84 yards, throwing three interceptions after not tossing one over the first four games.
The Sooners will head into the Red River Rivalry in Dallas next week with a perfect 4-0 record, while Ball State drops to 3-2 and awaits Temple in Muncie, Ind.