It's the largest loss for the Sooners (10-3, 0-1 Big 12) since a 92-68 drumming by West Virginia way back on Dec. 22, 2005.
And it really wasn't ever even close, barring the opening minutes.
After OU spotted Missouri the first seven points, it got to within 10-6 five minutes in and 20-16 at the 10:11 mark of the first half, but that's when it all changed.
The Tigers used a 19-7 stretch over the next few minutes to go up by 16.
They led by 18 at intermission.
Quickly out of the gates of the second half, the lead expanded.
Missouri seized a 32-point advantage with 12:39 remaining and led by as much as 42 with 5:22 to go.
Perhaps the only bright spot was the play of forward Andrew Fitzgerald, who finished with 18 points on 8-for-15 shooting, as well as six rebounds.
Guard Steven Pledger ended way short of his season-average, scoring just 11 points on 3-for-10 shooting, and no other Sooner finished in double figures.
Four Tigers managed double figures, led by guard Kim English, who had 23.
OU, which boasted the nation's fourth-ranked rebounding average per contest at 42.2 per game coming in, was smashed on the boards 38-23.
It was also out-shot 59.3 percent to 33.3 percent and outscored in the paint 36-10.