Early, it was guard Cameron Clark, who scored 10 first half points, that helped OU leap out to its large mark.
In the second half, forward Romero Osby and guard Steven Pledger anchored the Sooner sails and prevented the Cowboys from climbing clear over the top after trailing by double digits for most of the first half.
Osby scored 11 in the final 20 minutes and Pledger knocked down a pair of triples on his way to netting 12 after the break.
Because of that, OU was able to maintain the lead even despite a ridiculous 26-point flurry from OSU guard Keiton Page after intermission.
He finished with a game-high 29, draining 9-of-17 triples.
It can't be overstated, though, the performance from the Sooners on the defensive end to start the game.
They wreaked havoc for OSU in the half court, limiting it to just four first half field goals and 16.7 percent.
In fact, the Cowboys didn't score a single point until after the first media timeout and not a bucket until the 14:58 mark.
In the meantime, the Sooners converted 44.8 percent of their own and controlled the paint by a 12-0 margin.
OU would prove to win that battle by a 28-8 count.
The Sooners also dominated the boards throughout, racking up 47 in the contest to just 32 for the visitors.
So, the stats really don't lie; it was complete domination.
And much needed domination for the Sooners' psyche.
A team that hadn't won in nearly a month nearly again squandered a chance for victory in the second half, but pulled through on this night because of their attention to detail in so many areas.
The Sooners will now try to make it two in a row for the first time since recording back-to-back victories over Kansas State and Texas Tech on Jan. 14 and 17, respectively, when they head to Waco, Texas to face Baylor.
That game is slated for a 12:30 p.m. CT tipoff Saturday.