OU snagged its fifth straight victory and improved to 23-14, while it dropped the team head coach Sunny Golloway used to call his to 17-18.
"This place has so many great memories, eight years, and Rob [Walton] is like a brother to me," Golloway said. "It was good to be back. We are going to continue to play this series because it makes both teams better, no doubt. I am one of those guys that remembers where they came from and I will always be indebted to Oral Roberts and athletics director Mike Carter for giving me my start as a young head coach."
In this one, like the previous three outings, the Sooners fell behind early but bounced back.
Right fielder Cody Reine recorded the Sooners' first hit in the top of the fifth, and not longer after, designated hitter Evan Mistich doubled off the wall, plating Reine and center fielder Max White, who earlier reached on a walk.
Mistich scored third baseman Garrett Carey's sacrifice fly moments later.
Overton allowed just one run the rest of the way in picking up the win.
"When the situation came up, they called on me," said Overton, OU's normal Saturday starter. "It worked out good. I came into situations like that last year. It was nothing new for me."
In all, Overton finished with seven strikeouts, while allowing just four hits and no walks.
"It just set up for us to expand him there," Golloway said. "If we had a Big 12 weekend coming up, there's no way we could have let him go as long as we did. That was fortunate for us."
Left fielder Erik Ross' sacrifice fly in the top of the eighth gave OU a 4-2 lead and first baseman Hunter Lockwood ripped a two-run single in the ninth to complete the scoring after ORU tagged Overton for his only earned run in the previous half inning.
Mistich led the OU offense, going 2-for-3 with two RBIs and two runs scored.
The Sooners now host Alabama State in a three-game set over the weekend starting at 6:30 p.m. Friday at L. Dale Mitchell Park.