And like so many times in recent days, the recipe for this one was exactly the same: an offense that raked and solid pitching.
The Sooners pounded out their 12 runs on 11 hits, while pitcher Michelle Gascoigne surrendered just the one run on two hits.
Third baseman Lauren Chamberlain paced the Sooner offense, going 3-for-3 with three RBI and two runs scored, including her third inning homer that jumpstarted the scoring flurry.
OU then posted an 11-run fourth inning, which featured a two-run shot by shortstop Javen Henson and Chamberlain's second round tripper of the day, also a two-run bomb, as the two big blasts of the inning.
Left fielder Brittany Williams and designated player Katie Norris also added RBI singles in the inning.
With three home runs in the contest, OU now sits just one long ball away from tying the Sooner season record of 85 set back during the 2000 National Championship season.
Gascoigne picked up her 16th win of the season to just one loss.
The Sooners and Cyclones complete the three-game set with a 12 p.m. contest Sunday, as OU will be looking for the sweep to head into the postseason on a three-game winning streak.